Being a push-pull amp, probably with feedback, you must understand that this is not the most experienced forum! :^)
Being a guitar amp, it is likely to be overdriven. With a low load impedance, that makes it easier to drive it into current overload. If that drives one tube into cutoff, there are some issues with inductive kick - I remember reading that some guitar amp technicians add diodes somewhere to limit this effect, which can be quite destructive. I think it was in Pittman's book.
Finally, you said "The transformers are known for ... blowing up even when the speakers are matched correctly. Should I be concerned?" Well, yes, I would be. Even with a matched speaker! :^)