I have some experience with a similar setup for my father's. There are many options, but your ideal solution depends on your other constraints. For instance: which source/amp/speaker components can you co-locate (based on your example, all can't be together), can you string wire (either interconnect or speaker [location of SEX dependent], either in wall or on floor), how much control do you want at one end of the room or the other, and how much $$ is a factor.
I'll skip to the end & say my father had me configure an Audioengine D2 wireless DAC (he gave up a Squeeze Box that was giving him trouble). It solved his unique problem with plug-n-play efficiency, but at a cost could have funded a new music serving computer co-located with his amp/speakers for his non-audiophile tastes. In his case he specifically didn't want another computer, was willing to pay for not having wires, and wanted the music for more background noise than involved listening. I haven't spent the time around his music collection to fully evaluate sound quality (nor does he have the BH gear to appreciate it), but it moves the bits from a mac mini to his big box store receiver with RCA inputs.
In my own listening setup, I've gone to other lengths to optimize sound quality. I've had a NAS-based music collection for more than a decade, so my priority has been to deliver the network cable to the vicinity of the amp, where I've put a receiving device and DAC (music server, network enabled Oppo, etc). I prefer this due to the control it gives me and minimizing the number of conversions, but YMMV.
Cheers,
Bill
