PJ covered the AC side. On the DC side with the Speedball, the plate voltage on the 12AT7 will rise to maybe 125V, which doesn't leave a lot of operating voltage for the 6080. This will also increase the voltage across the Speedball large PC board and will increase heating of those components. The plate voltage will be a bit lower in the stock circuit, but you'll be loading a tube with an Rp of around 15K at that operating point with a 22.1K resistor, so THD will be pretty high and you get back to PJ's point about needing more voltage.
Why do you want more gain in your Crack?