My last system incarnation was like you describe -- Foreplay III into a DCX2496, then active bi-amp into two-way box speakers. Worked out OK. The only hassle was that the DCX uses XLR inputs and outputs, so I had to build a simple little converter box. The DCX also likes "professional" +4 dBu instead of the typical -10 dBV line level out of your CD player, which I handled simply by feeding the DCX a much louder signal than usual and then padding by -12 dB with passives in the converter box.
The resulting sound was a good one, particularly precise with respect to imaging. The only room-specific tweaking I ever did with the DCX was damping some major room modes below 50 Hz, but it's not really precise enough to do this correctly. As far as the crossovers themselves, you basically set it and forget it.
However, in my ears's opinion, you get a much bigger effect with relatively insensitive drivers and/or replacing crossovers with a lot of attentuation. Odds are, if you're using tube amplifiers, you're not using these kinds of speakers. With high-efficiency speakers, horn loaded and big efficient drivers, I'm not convinced it's worth the extra amplifiers.
For my next system I'm going high-efficiency. So, the DCX is no longer in the signal chain. It's also not the most rugged piece of equipment. Pretty powerful for the price, though.