I just saw this thread and started writing in response before I realized it is a few months old.
FWIW, what aroide was describing sounds very similar to what I heard when I upgraded my Mac Mini to OS 10.10.5 - a painfully harsh chopped kind of sound, like the music was literally going through some kind of chopper (intermittently cutting out time-slices). Recognizable as music, yes, but beyond unlistenable.
In my case, after restarting, then being sure Amarra was running, the problem seems to have gone away, though the sample rate display seems to read 44.1 all the time, even when playing higher-res files - I am still trying to test that more thoroughly, though.