So to convert that to watts, I use I= P * E? so if I have 70 mA with 400 volts, I get 400 * .07 equals 28 watts.
You did the right calculation, though the equation is P=I*E. I'm guessing algebra was a long time ago? :^) More accurately, as PB pointed out, is 0.07 amps times 350 volts equals 24.5 watts. This is within the absolute maximum for the EML mesh (28 watts), but not the recommended maximum of 22 watts. It is, however, one of the recommended operating points according to EML.
so for a target of 22 watts (recommended for the Meshplate), with 400 v, I would want 5.5 mA. I would use the trimpots to get my desired current.
To maintain the performance, it's better to keep the ratio of voltage to current constant. This ratio is technically called the "beam resistance" since it has the dimension of resistance - in this case 5000 ohms. I get 66.3mA at 331.5 volts.
None of the three trimmers/potentiometers per channel has any effect on the plate current or voltage of the 300B. The simplest way to reduce the dissipation while preserving the beam resistance is to reduce the plate-to-cathode voltage to 330 volts. The 1000 ohm bias resistor will automatically reduce the current to correspond. There are some resistors in the power supply that can be increased a bit to get there if it seems necessary.
It is possible to increase the bias resistor a bit to bring the current down - I get 1161 ohms. The beam resistance then is about 5500 ohms, which is higher than I normally design for, but it's not far off. This is one of the EML recommended operating points, so you may be happy with it.
My recommendation would be to run it stock at first, and post the voltages you get with your power line voltage. Then adjustments (if desired) can be based on facts rather than predictions.
Incidentally, the filament current in this tube is 1.4 amps, not the 1.2 amps of a standard 300B. The filament voltage will be reduced about 5%, so the series filament resistors might also need to be changed. Again, it's best to measure it stock before modifying so that the mod is based on actual measured voltages.
As you can see, using a non-standard tube is a little complicated!