The thread has gotten too long to figure out what has already been checked, and it's unclear whether the C4S has been replaced or not. (At one time the noise was thought to have originated in the C4S?) So maybe a status summary would help. Is it in one channel or both?
From the description, it seems most likely to be a mechanical connection problem, such as a bad solder joint, bad tube socket connection, bad pot, broken part, etc. Nothing bad enough to be obvious, just enough that the connection comes and goes. It might be time for the chopstick test.