Most likely. I think the 47uF@450 would benefit from an upgrade too.
The 22uF is closest to the driver tube plate, the 47uF is closest to the output plate. I'm thinking that the output is more important. Like upgrading audio path caps, the output cap is more important, more bang for the buck, than the interstage. Both make an improvement.
If you are going to place an order why not get caps for both?