Yes, the Mainline will drive a power amp, quite well, even with very long interconnects.
During our investigation of better preamps, the Mainline configuration (shunt regulated, current source loaded, single ended triode with parafeed output transformer) would probably have won, if Doc B had not kept pushing for a 300B. The BeePre circuit with other triodes was not quite cutting the mustard. Because a headphone amp needs an output transformer, we went back to that configuration for the Smack, and eventually refined it as the Mainline.
I love the sound of the BeePre, but if I didn't have one I'd use a Mainline, or a Smack, in a heartbeat.