You could overdrive the tube by putting a lot of signal into the Mainline and leaving the level control all the way up.
Negatives:
1. It will be too loud to listen to.
2. There will be a lot of distortion.
3. It won't sound good.
Positives:
I can't think of any.
In the Mainline, the current through the tube is independent of the bias, as a constant current source is used as the load. The bias voltage is set to obtain the perfect plate voltage, which allows for maximum power output of the amplifier.
If you rebiased the amp to take more input voltage, it would actually end up making less power.
-PB