It's likely a loose connection, maybe even something as simple as a loose speaker wire.
You can swap the 2A3 tubes from side to side and the 12AT7s from side to side to rule them out.
Actual components like resistors, transistors, and capacitors will tend to produce wildly off DC voltages and smoke when they fail, so you definitely do not want to start pulling parts because you think one is bad. This kind of effort will generally make more problems that also need to be solved.