(I hit "post" right as PJ posted, but I'll leave the overlap anyway)
I've built a 6C33 SET amp, so I can offer some commentary.
First and foremost, a 6C33 is not a directly heated tube, and therefore suffers a little bit in terms of linearity when compared to a 2A3 or 300B. In my own project, I found that a little bit of global feedback helped straighten that out a lot, but that imparts its own issues that you have to be prepared to deal with.
Another strike against the 6C33 is the heater current required to make the tube operate. I had to be very, very careful when selecting tube sockets for the 6C33, as many of them would not support the heater current requirement. Each 6C33 needs about 7A of heater current, and even my 6.3V/20A dedicated filament transformer groans a little bit when I turn the amplifier on!
On the good side, the 6C33 can be operated at pretty safe voltage levels and doesn't need a particularly insane amount of high voltage current. It is also pretty easy to make a nice 600 Ohm/20W gapped output transformer, but the size of the requisite parallel feed capacitor makes series feed a more sensible choice.
Ultimately, since the 6C33 isn't directly heated and needs feedback anyway, the more common approach is to run a 6550 or KT-88 at near maximum operating conditions for roughly the same power. The same could ultimately be done for a 300B with reduced tube lifetime expectations.
As far as 6C33 lifetime goes, I have found them to last much, much longer than 750 hours (I'm still on my first pair, and the amp is almost 10 years old, though it doesn't get a lot of use now).
-PB