Hello again, it seems you were spot on.
Replacing only the 'top' 2N2222A resulted in all of the LEDs lighting up minus one on the large PCB and led to very different voltages between A & B side connections. Before attempting to replace the TIP50, I thought I may as well replace that LED and that seems to have done it. I think that LED is the one in parallel to R1 in the circuit diagram, I guess that blew along with the 2N2222A.
Now all LEDs light up evenly, and voltage checks pass. I've run it for an hour now the 270 Ohm resistor is pretty hot but not overly (I turn it off and touch it carefully). In any case it's not smoking!
The only thing is that the upgrade seems to have exposed a usb/ground loop noise from my DAC and PC, but I can fix that.
I have to say while i enjoyed making and listening to the solo-crack I was a slightly underwhelmed by it, so I was hesitant to invest more in it with the upgrade, but to my ears the speedball + crack sounds brilliant. Instruments are much more defined and present without losing any musicality. Vocals especially sound so much better.
I'm really pleased with it, thanks again for assistance.