Yes, the carbon composition resistors (220 ohms) are fairly fragile, and an internal crack could easily let some signal through imperfectly, affecting the sound.
I'm not sure this is what you are describing, but the glow on the internal surface of gas regulator tubes such as the 0D3 will usually only cover a portion of the surface. When it covers the whole surface, the tube is saturated and can't regulate any more.