The way panels generally work is that two breakers that are right next to each other will be on separate branches of the main feed. This lets you slot in a 240V breaker to feed a water heater, range, dryer, etc. and conveniently get 240V wherever you put a double wide breaker.
Since A and B are right next to each other and you have quiet operation elsewhere in the house, this is good news in a way!
Ah, was hopeful there for a second that moving the breaker to the other side might fix it. But happy to be ruling out potential causes all the same!
To rule out the possibility that external interference is just particularly bad in your upstairs, you could run an extension cord from line "C" to upstairs and plug the crack in, putting the crack in one of the spots where you previously got the chirps on line "A" or "B".
Thanks for this suggestion -- I tested this over the weekend, and I think the evidence is pointing toward external interference. I plugged a 100' extension cord into "C". When I'm downstairs, no chirping. When I go upstairs, I get the chirps. Moreover, it varies in volume based on my location upstairs. Not a huge space (2 rooms and a hallway, ~300 sq ft total), but I can hear the chirping anywhere upstairs, and it is:
• quietest when I put the amp on the ground
• louder at waist/desk level
• loudest of all when I hold the amp over my head and place it near the south wall.
The south wall has 2 old phone lines (no signal, as far as I know) and a fiber optic line coming into the house from the street. However, those lines first hit the house below the upstairs, and my sense was that fiber optic wasn't likely to emit interference due to light and all that (true?). I've read about interference in the context of a nearby wireless device, where you hear intermittent noise as the device is transmitting/receiving. So I'm baffled about what a source of interference could be that is causing such a regular, consistent pulse, and a strong signal that's detectable over a wide area of the house.