If you have the sort-start upgrade or the Version 1.1, then you would not normally exceed the 215 volts. If you have the older version, then you will always risk approaching 450 volts on startup. If the soft-start is misadjusted (as it might be when a tube is swapped), or if the driver fails, or if the driver socket fails, you are again at risk of approaching 450 volts. If the capacitor fails shorted, as electrolytics do sometimes, you risk consequent damage to the 2A3.
Those are the reasons that a 450v capacitor is specified.