Upside in the base is perfectly fine, or as i built mine upside down in a cardboard box while to varnish dried on the base.
For safety (read the manual intro again) unplug the mains lead from the wall, place the amp upside in the box/base with the power switch on and mains lead connected, connect multimeter - lead, then plug it into the wall and carefully take measurements. The back of the mains switch/plug on the amp is just as dangerous so you dont want to be fumbling around for the switch when its all live.
The process is a little unnerving, especially on the S.E.X. amp where some of the points are a little awkward to get at and have over 400v DC on them. It reminded me of the game "Operation" where you had to remove parts with tweezers without setting off the buzzer
Basically just take your time and be careful of what you are doing so you dont short anything out, and again, read the manual as there are some very good safety points in there like insulating yourself by wearing shoes, keeping one hand in your pocket, and especially do not touch the amp with both hands.
As a rule i never lift the chassis plate with the AC cord connected, i'm just paranoid about those live terminals.