One thing that probably hasn't been stressed enough here is that we tend to ignore reference when we refer to things like the Voltage at thus-and-such node in a circuit, probably as a form of verbal shorthand because everyone "knows" what the reference point is by custom when discussing the various parts of a circuit.
For instance, when discussing negative bias on the grid of the tube, it is more accurate to say that the Voltage developed on the grid is negative with respect to the cathode. While "ground" is often the reference point, in the case of the input stage to the SEX amp (and many, many other common tube amplifier stages), the Voltage on the grid is only negative with respect to the cathode. As others have explained, this is accomplished in practice by making the cathode positive with respect to ground while the grid is held essentially at ground potential.
You can, of course, verify this with your meter: Measure the Voltage from grid to ground, then cathode to ground. You will find little if any Voltage at the grid with respect to ground. At the cathode, you will find positive Voltage with respect to ground. Then, measure between the actual grid pin and the actual cathode pin. The difference you will see in the potential between these two points is the bias. If you use the cathode pin as the reference point (black lead on your DMM), with the red lead on the grid, you will see "negative" Voltage.
It is important to note, again, that the "polarity" of the Voltage is also relative depending on which meter lead you apply to which pin. With a DMM, you can switch the red and black leads back and forth, and the only difference will be whether there is a + or a - before the reading. Back in the day when mechanical meters often only went in the positive direction from zero, it was rather important to make a good guess as to which direction the Voltage was going before you attached the leads of the meter to the circuit! Most meters would not react well to a "negative" Voltage applied for a long period of time, and the higher the Voltage the more severe the reaction might be!
All of this is to point out that a Voltage reading taken with a meter is literally only the difference in potential between the two leads of the meter. It is only pertinent information in the context of that very exclusive little world.
In the larger sense, a Voltage is always nothing more than the potential difference in electro-motive force between two specified points; it is always relative to that context and essentially meaningless otherwise.
Another good example in your tube data sheet is the "Maximum Plate Voltage" specification; although the reference point may just be assumed, it means "Maximum Plate Voltage with respect to the Cathode". IOW, if the potential on the Cathode is 100 VoltsDC with respect to ground, and the potential on the Plate is 300 VoltsDC with respect to ground, then the potential difference between the Plate and the Cathode is 200 VoltsDC. If the Cathode is the reference point, then the Plate will be said to be 200 Volts positive with respect to the Cathode.
I apologize if this seems a bit pedantic, but, trust me, as you gain more experience with circuit analysis or even just troubleshooting, these fine points will take on more importance.