The 4V at Kreg isn't a problem, the regulator will still operate. IIRC, there was an error in the manual and it looks like we haven't corrected the Kreg voltages to be a large enough range.
A b-side C4S may or may not be tube related. If a 6C45 doesn't glow, and whichever 6C45 you put in the same socket won't glow, then you have an issue at that socket. If the 6C45 isn't glowing, the B side LED's over it won't light up, and OB is going to be pretty high.
-PB