I would replace the whole board. The only connection from the high voltage DC to that board goes through some high impedance resistors to the LED's, then to ground. Having the high voltage section short out is almost always an issue of proper mounting of the TIP50 transistors, which can be confirmed by pulling the 6080 tube and observing that the problem goes away.
In your case, that doesn't happen. That leaves us with a wiring or component installation mistake that has never been made before in the history of the Speedball, or potentially the wiring of the 8 pin socket is such that the original build would've produced the same problem. There's also the potential problem that the base guiding pin has broken off of your 6080 and it isn't being properly inserted, which is creating the short.
Sending the amp in for repair is also another option in this scenario.